UC & Bladder Cancer Testing (MUrine)
Why choose the MUrine test?
85% of bladder cancer patients exhibit painless hematuria as an initial symptom, where blood is present in the urine. Traditional testing methodologies such as imaging and cytology has been shown to have low sensitivity, prompting better tools to screen for bladder cancer. However, this traditionally comes in the form of cystoscopies, which are highly invasive, uncomfortable, and requires anesthesia. Murine sits in the middle, harnessing DNA methylation biomarkers in urine to determine whether there is further need for cystoscopy in high-risk cases, or regular cytology examinations in low-risk cases. It is non-invasive and painless, which prevents unnecessary invasive cystoscopies in cases where painless hematuria is not necessarily an indicator of bladder cancer.
For early detection of uriary tract abnormalities
What is the procedure for UC & bladder cancer testing?
- Patients come in for initial consultation with physicians
- Physician explains screening protocol and informed consent
- Patient urine samples are collected using a marked cylindrical tube
- Processing of samples and DNA extraction
- qPCR preparation via bisulfite conversion
- qPCR amplification
- DNA methylation analysis
- Patients are notified of results
- Interpretation of lab results are discussed with the patient
- Professional evaluation and suggestions are made to the patient